ASD-CARC :: Researchers: Hymie Anisman

Hymie Anisman, PhD

email: hanisman@ccs.carleton.ca

Click here to visit his website

SUMMARY OF RESEARCH:

- Stressor induced neurochemical changes: Genetic and ontogenetic factors

- Influence of stressors on immune functioning

- Cytokines and stress in relation to neurochemical change and behaviour

- Cytokines and depression - Impulsivity and anxiety

- Psychosocial stress

RELEVANT PUBLICATIONS:

Stressor Effects: Neurochemical and Behavioral sequelae

Caldji C, Diorio, J., Prakash, P., Anisman H., Meaney, M.J. (2004) Maternal behavior regulates Benzodiazepine/GABAA receptor subunit expression in brain regions associated with fear in BALB/cByJ and C57BL/6ByJ mice. Neuropsychopharmacology, 29, 1344-1352.

Merali, Z., Michaud, D., McIntosh, J., Kent, P. & Anisman, H. (2003). Differential involvement of amygdaloid CRH system(s) in the salience and valence of the stimuli. Prog. Neuro-psychopharmacol. Biol. Psychiat. 27, 1201-1212.

Tannenbaum, B.M., Tannenbaum, G.S. & Anisman, H. (2003) Impact of life-long macronutrient choice on neuroendocrine and cognitive functioning in aged mice: differential effects in stressor-reactive and stressor resilient mouse strains. Brain Research 985, 187-197.

Michaud, D.S. McLean J., Keith, S.E. Ferrarotto C.,.Haley, S., Khan, S., Anisman, H.& Merali. Z. (2003). Differential impact of audiogenic stressors on lewis and Fischer rats: behavioral, neurochemical, and endocrine variations. Neuropsychopharmacology. 28, 1068-1081.

Tannenbaum, B. & Anisman, H (2003). Impact of Chronic Intermittent Challenges in Stressor-Susceptible and Resilient Strains of Mice. Biol. Psychiat, 53, 292-303.

Stressor effects: Immune and cytokine sequelae

Anisman, H. & Kusnecov, A. (2004). Stress and immunity in the rat. In Ian Q. Whishaw and Bryan Kolb (Eds.), The Behavior of the Laboratory Rat: A Handbook with Tests, Oxford University Press, Inc.

Kusnecov, A. & Anisman, H. (2004). Stress and Cytokines: Implications for cancer and its treatment. In C. Kaiser (Ed). Cancer growth and Progression. Kluwer Press, Boston. In press

Anisman, H., Hayley, S. & Merali, Z. (2003). Neurochemical sequelae of cytokine activation: Parallels with stressor effects. Seventh Symposium on Catecholamines and other Transmitters in Stress. R. Kvetnansky (ed). Slovak Acad. Sci. in press.

Cytokine-Brain interactions

Anisman, H. (2004). Considering cytokine panels. Brain Behavior & Immunity. 18, 221-222.

Sudom, K., Turrin, N., Hayley, S. & Anisman, H (2004). Influence of chronic interleukin-2 infusion and stressors on sickness behaviors and neurochemical change in mice. Neuroimmunommunomodulation 11, 341-350.

Hayley S, Kelly, O.P. & Anisman, H. (2004). Corticosterone changes in response to stressors, acute and protracted actions of tumor necrosis factor-a, and lipopolysaccharide treatments in mice lacking the tumor necrosis factor-a p55 receptor gene. Neuroimmunomodulation, 11, 241-246.

Anisman, H., Turrin, N.P., Merali, Z. & Hayley, S. (2003). Neurochemical Sensitization Associated with Systemic Administration of Tumor Necrosis Factor-a: Adjuvant Action in Combination with Bovine Serum Albumin. J Neuroimmunol, 945, 91-102.

Merali, Z., Brennan, K., Brau, P.& Anisman, H. (2003). Dissociating Anorexia and Anhedonia Elicited by Interleukin-1b: Antidepressant and Gender Effects on Responding for "Free Chow" and "Earned" Sucrose Intake. Psychopharmacology, 165, 413-418.

Hayley S, Kelly, O.P. & Anisman, H. (2003). Corticosterone changes in response to stressors, acute and protracted actions of tumor necrosis factor-a, and lipopolysaccharide treatments in mice lacking the tumor necrosis factor-a p55 receptor gene. Neuroimmunomodulation, in press.

Anisman, H., Hayley, S. & Merali, Z. (2003) Sensitization associated with stressors and cytokine treatments. Brain Behav. Immun. 17, 86-93.

Hayley, S., Merali Z. & Anisman, H. (2003). Cytokine-elicited sensitization: neuroendocrine, neurotransmitter and behavioral responses. In Z. Kronfol (Ed.). Cytokines and Mental, Kluwer Academic Publishers.

Depression: Pharmacotherapy, neuroendocrine and cytokine functioning

Anisman, H. & Matheson, K. (2004) Anhedonia and Depression: Caveats Concerning Animal Models. Neurosci Biobehav Rev. (in press)

Hayley, S., Poulter, M. Merali, Z. & Anisman, H. The pathogenesis of clinical depression: From stressors to growth factors. Brain Behav. Immun. (in press).

Anisman, H., Poulter, M. Merali, Z. & Hayley, S. (2004). Inflammatory immune activation as a Precipitant of Depressive Illness. Curr. Pharmaceut. Design. (in press).

Hayley, S., Merali, Z. & Anisman, H. (2003). Stress and Cytokine-elicited Neuroendocrine and Neurotransmitter Sensitization: Implications for Depressive Illness. Stress, 6, 19-32.

Anisman, H. & Merali, Z. (2003) Cytokines, Stress and Depressive illness: Brain-Immune Interactions. Ann. Med. 35, 2-11.

Impulsivity and Anxiety Merali Z., Khan, S., Michaud, D.S. Shippy S. & Anisman H. (2004) Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH release. Eur. J. Neurosci... 20, 229-239.

McIntyre, D.C., McLoed, W.S., & Anisman, H. (2004). Working and Reference Memory in Seizure Prone and Seizure Resistant Rats: Impact of Amygdala Kindling. Behav. Neurosci. 118, 314-323.

Kelly, O.P., McIntosh,J., McIntyre, D.C., Merali, Z. & Anisman, H . (2003) Anxiety in rats selectively bred for fast and slow kindling rates: situation-specific outcomes. Stress 6, 289-295.

Merali, Z., Levac, C. & Anisman, H. (2003). Validation of a Simple, Ethologically Relevant Paradigm for Assessing Anxiety in mice" Biol. Psychiat. 54, 552-565.

Psychosocial Stress

Mantler, J., Matejicek, A., Matheson, A. & Anisman, H. (2004) Coping with employment uncertainty: A comparison of employed and unemployed workers. J. Occupat Health Psychol. In press.

Matheson, K., Cole, B., Tannenbaum, B., Dodd, C. & Anisman, H. (2004) Parental Bonding and Depression: The Mediating Role of Personal, Social and Coping Resources. Br. J. Soc. Psychol. in press.

Matheson, K. & Anisman, H. (2003) Systems of Coping Associated with Psychological Distress: A Profile Perspective. Stress. 6, 223-234.

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